国产培氟沙星临床疗效观察

A CLINICAL STUDY OF PEFLOXACIN

本文用国产培氟沙星对多种感染性疾病进行临床疗效观察。采用随机分组对照,治疗各种感染38例,并于同期用头孢氨苄治疗呼吸道感染,诺氟沙星治疗肠道及泌尿道感染36例进行比较。培氟沙星治疗呼吸道、肠道及泌尿道感染的临床有效率分别为90％、92.9％和88.9％,细菌阴转率为100％、100％和88.9％;使用头孢氨苄和诺氟沙星的对照组临床有效率分别为90％、57.1％和77.8％,细菌阴转率为100％,78.5％和77.8％。结果显示培氟沙星在肠道感染中疗效优于对照组,其它各组疗效与对照组无显著差异。本品副反应发生率为16.2％。

To determine the clinical efficacy and safety of pefloxac-in in various infections, a randomized trial was conducted. 74 patients were admitted into this study, including 20 casee of respiratory tract infect- ion, 29 cases of enteric infection, 18 cases of urinary tract infection and 7 cases of other infections. The effective rates of pefloxacin were 90%, 92.9% and 88.9%, respectively. Bacteriological eradication rates in the pe floxacin groups were 100%,100% and 88.8%,respectively. The clinical ef iective rates and bateriological eradication rates of pefloxacin were the same (respiratory and urinary tract infections) or better (enteric infection) than those of the control groups. Side-effects occurred in 6 patients( 16.2% ), including 1 patient with psychiatic symptoms.The authors conclude that pe-floxacinis a safe and effective agent in the treatment of various infections.