磁场对肿瘤细胞的抑制作用

Restraining Solid Tumor S180 & P388 in Mouse by Magnetic Field

目的 :用磁场进行小鼠荷瘤和人体的离体癌细胞抑制试验。方法 :用装备有NdFeB永磁材料的仪器产生非均匀磁场 (磁通密度为 0 .2 0T ,梯度为 0 .0 7T/cm)对荷瘤小鼠和人体的离体癌细胞每天作用0 .5小时 ,1 2天后解剖检查试验结果。结果 :磁场对荷瘤小鼠的癌细胞抑止率达 61 % (p <0 .0 0 2 ) ,胸腺平均比化疗组重 8mg(p <0 .0 1 ) ,癌组织的纤维包膜是对照组的 2～ 3倍。谷丙转氨酶 (SGPT)低于化疗组的平均值 (p <0 .0 0 1 ) ,肝、心肌细胞无损伤 ;白细胞 (WBC)高于化疗组的平均值 (p <0 .0 2 ) ,免疫功能提高 ;血红蛋白 (Hb)低于化疗组的平均值 (p <0 .0 5 ) ,局部缺氧 ,癌细胞呈片状坏死 ,部分癌组织呈孤岛状。磁疗组无明显毒副作用反应。重复性实验结果相近。小鼠和人体离体癌细胞实验显著性检验无显著性意义。结论 :磁场在一定的梯度范围是可以有效的抑制小鼠肿瘤的生长。

Objective: To try the experiments of restraining the solid tumor in mice body and the cancer cell departed from the human. Methods: Treating mice by the instrument, which equipped with NdFeB permanent magnets (magnetic induction=0.20T,magnetic grandiet=0.07T/cm) 30s every one day and after 12 days to dissect and examine. Results: The experiment has results in a tumor-restraining rate of 61%(p<0.002) in mice. The average weight of the thymus of the mice treated by magnetic device is 8 mg heavier than those of the mice treated with Bleomycin(p<0.01). The integument of the tumor of the magnetic fields treated mice are 2～3 times as thick as that of the control group of mice. SGPT of the magnetic fields treated are lower than Bleomycin group (p<0.001); WBC is higher than Bleomycin group (p<0.02) and Hb is lower than Bleomycin (p<0.05). Conclusion: There is an efficient restraining tumor in mice and not any poison and side effect obviously.