抗甲氧西林金葡球菌耐药性的研究

STUDY ON RESISTANCE TO ANTIMICROBIAL AGENTS OF MRSA

抗甲氧西林金葡球菌(MRSA)感染发病率有逐年增加趋势。为了解MRSa耐药特点及合理选用抗菌药物,本文测定了18种抗菌药物对临床分离金葡球菌(SA)的最低抑菌浓度(MIC)、受试菌的β-内酰胺酶及凝固酶分型。结果表明MRSA占临床分离SA的50.7％,其中产β-内酰胺酶菌株占85.1％,MRSA凝固酶均为Ⅱ型。MRSA对多数β-内酰胺类及某些氨基糖苷类抗生素呈多重耐药性。万古霉素、Arbikacin对MRSA显示最强的抗菌活性;二甲胺四环素、丁胺卡那霉素、Tosufloxacin、Imipenam亦显示较强抗菌活性,提示上述抗菌药物可用于MRSA所致严重感染。

The morpidity of the infections caused by MRSA was increased with years. In order to know resistance to antimicrobial agents of MRSA, the minimum inhibitory concerntrations (MICs) of antimicrobial agents against S. aureus isolated from patients β-lactamase and type of coagulase of the strains tested were measured.The results showed MRSA was account for 50.7% of the strains tested, the incidence of MRSA producing β-lactamase were 85.1%, the coa-gulase of MRSA was type I. MRSA showed multiple-resistance to the most of β-lactam antibiotics and some aminoglycosides. Vancomycin and arbikacin had the highest activity against MRSA, the other drugs were in the follwing order: minocycline, amikacin, tosufloxacin, imipenam and cloxacillin. It suggested that serious infections caused by MRSA may be cured by using the vancomycin, arbikacin or other drugs mentioned above.