呋喃坦啶的吸附伏安法研究

Adsorption Stripping Voltammetry of Furadantin

研究了呋喃坦啶(FDT)在0 1mol LHAc＿NaAc(pH=4 0)中于悬汞电极(HMDE)上的电化学行为。在-0 1～-0 5V(vs SCE)内FDT在悬汞电极上产生一不可逆的还原电流峰,峰电位为-0 28V(vs SCE),电流峰具有吸附特性。实验测得电极反应的电子转移数、转移系数和参与电极反应的H+数分别为4、0 63和4。考察了吸附富集时间、扫速和FDT浓度等因素对电极过程的影响。提出了电极反应机理。建立了对FDT测定的吸附溶出伏安法,峰电流与FDT浓度在8 0×10-9～5 0×10-6mol L范围内呈线性关系,检出限为5 0×10-9mol L。该法用于片剂中FDT含量的测定,得到满意的结果。

In 0.1 mol/L HAc_NaAc (pH 4.0) solution, a sensitive reduction wave of furadantin was observed on the surface of HMDE. The peak potential is -0.28 V(vs\^ SCE). The reduction wave was shown to be irreversible with adsorptive characteristics. Some electrochemical parameters such as electron transfer numbers(n=4), transfer coefficient(α=0.63) and proton numbers(n=4) were determined respectively.Effects of preconcentration time, scanning rate,and concentration of the FDT on the electrode process and the electrode reaction mechanism of FDT were studied by means of linear sweep and cyclic voltammetry. The linear range between the peak current and the concentration of furadantin is 8.0×10^(-9)～1.0×10^(-6) mol/L. The detection limit is 5.0×10^(-9) mol/L. This method has been used to determine the content of furadantin in medical tablets.