摘要
为验证沙棘籽油和沙棘果油对过敏性皮炎患者皮肤表层粗糙程度的影响 ,进行了有安慰剂对照的平行性研究。 1 6位患者在 4个月内每日分别服用 5 g沙棘籽油 ,沙棘果油或石蜡油。本研究包括皮肤表面粗糙程度的测量方法和测量参数的优化选择以及服油前、后手背和肩部非病变区皮肤表面的粗糙程度的测量。实验结果表明 ,服油前后皮肤表面的粗糙程度无明显统计学变化 ,说明沙棘油对过敏性皮炎患者非病变区皮肤的影响小于对病变区皮肤的影响。由于本研究中患者人数有限 ,此结论有待进一步验证。用表面光度测量仪可明显指示不同部位皮肤表层结构和粗糙程度的差异 ,在对皮肤的研究方面有广泛的应用前景。
A placebo-controlled, parallel study was carried out to investigate the effects of oils from seeds and soft parts of seabuckthorn (Hippophae rhamnoides) berries on the surface roughness of non-symptom skin area of patients with atopic dermatitis. Thirteen patients took 5 g of seed oil, soft part oil or paraffin oil daily for four months. A method for profilometric measurement of skin surface was optimized; and the roughness of skin surface of the lesion-free areas on the dorsal aspect of hands and the shoulder region of the upper extremity was measured before and after the dietary oil treatment. No statistically significant changes in skin surface roughness were observed after the oil treatment, suggesting less effect of seabuckthorn oils on the lesion-free area compared to the lesion areas of atopic skin. Further investigation is needed to verify the conclusion due to the small number of patients included in this study. The profilometric measurements showed clear differences in skin surface structure and roughness at different locations. The optimized method may be useful in dermatological study and in the evaluation of skin care products.
