甲氰咪胍辅助治疗带状疱疹20例分析

Observation on the therapeutic effect of cimitidine on 20 herpes zoster patients

目的 对比观察阿昔洛韦联合甲氰咪胍与单用阿昔洛韦治疗带状疱疹的疗效。 方法 观察组予阿昔洛韦 0 2 5g静脉滴注 ,每天 3次 (每隔 8h 1次 ) ,同时予甲氰咪胍 0 4g静脉滴注 ,每天 2次 ;对照组予阿昔洛韦 0 2 5g静脉滴注 ,每天 3次 (每隔 8h 1次 )。分别于治疗后第 1、3、7和 11d观察疗效。 结果 观察组和对照组第 1d有效率分别为 70 %和 40 % (χ2 =6 67,P <0 0 5 ) ,第 3d分别为 85 %和 70 % (χ2 =4 2 ,P <0 0 5 ) ,两组对比差异有显著性 ;第 7d痊愈率分别为 90 %和 60 % (χ2 =4 8,P <0 0 5 ) ,第 11d天分别为 10 0 %和 80 % (x2 =4 4,P <0 0 5 ) ,两组对比差异有显著性。 结论 阿昔洛韦联合甲氰咪胍治疗带状疱疹疗效比单用阿昔洛韦起效更快 ,疗效更高 ,疗程更短 ,值得临床推广应用。

Objective To observe the therapeutic effect of cimitidine in combination with aclovial and aclovial alone on 20 herpes zoster patients. Methods Patients in the observation group were intravenously given aclovial 0 25g,three times per day (one time for every 8 hours) and 0 4g of cimitidine was simultaneously given,two times per day;the patients in the control group were intravenously given 0 25g aclovial,three times per day (one time for every 8 hours).The therapeutic effect was observed on the 1 st ,3 rd ,7 th and 11 th day after treatment Results The effective rates were significantly different in the observation group and control group on the 1 st ,3 rd ,7 th and 11 th day being 70% and 40%(χ 2=6 67,P<0 05),85% and 70%(χ 2=4 2,P<0 05),90% and 60%(χ 2=4 8,P<0 05) and 100% an 80%(χ 2=4 4,P<0 05),respectively. Conclusion The combination of aclovial with cimitidine is more effective than that using aclovial alone for treatment of herpes zoster patients and is worthy of popularization.