43例烧伤患者免疫功能分析

Analysis of immune function of 43 burned patients

目的 了解烧伤患者免疫功能改变情况及其与医院感染率的关系。 方法 对 43例烧伤患者及 41例正常体检者进行多参数测定 ,主要测定B细胞、T细胞亚群 (CD3 、CD4、CD8)、中性粒细胞趋化功能、吞噬细胞吞噬杀菌功能、C反应蛋白 (CRP)及前列腺素E2 (PGE2 )、β 内啡肽 (β EP)等指标 ,对每一参数作统计学分析。 结果 烧伤患者B细胞活性无明显改变 ,T细胞总数下降 ,尤以CD4明显 ,CD4/CD8比值也下降 ,中性粒细胞趋化功能及吞噬杀菌功能均减弱 ,CRP含量明显升高 ,PGE2 及 β EP均明显升高 ;医院感染率高于同期住院普通患者。 结论 烧伤后机体呈非特异性免疫功能及特异性免疫功能均受损 ,是患者容易发生医院感染的原因之一。

Objective To study the relationship between the changes of the immunologic function in burned patients and the infection raet in hospital. Methods The related parameters,including the function of B lymphocyte and Tlymphocyte su Bsets(CD 3,CD 4,CD 8),the chemotaxis of neutrophilic granulocyte,the phagocytic and bactericidal function of phagolytes,and the levels of sencm C reactive protein(CRP),prostaglandin E 2(PGE 2),β endorphin(β EP),were measured and statistically analysed in 43 burned patients with and compared with 41 health subjects. Results The activity of B lymphocyte in burned patients had no change,the amount of T lymphocyte decreased,especidlly CD 4,the proportion of CD 4 and CD 8 was also low.Both the chemotaxis of neutrophilic granulocyte and the phagcytic and bactericidal function of phagolytes weakened,the levels of CRP,PGE 2 and β EP in burned patients were obvionsly higher than that in the healthy control group,the infection rate in hospital is higher than that of common patients in the same period. Conclusion Both non special and special immunologic function in the patients after burn were impaired,which is one of the cause the patient were vulnerable to infectian in hospital.