儿童锌卟啉水平及影响因素调查

A Survey of the Level and Influence Factors of Protoporphyrin in Children

目的 研究工业区儿童锌卟啉水平及其分布规律。方法 选择武汉市青山区 335名 3～ 7岁正常儿童进行锌卟啉流行病学调查。内容包括锌卟啉 (ZPP)、Hb、身高、体重测定 ,计算体格指数 ,并对年龄、性别、是否补锌、补钙、补铁、父母双方职业、文化程度、吸烟、饮酒、家庭经济状况进行问卷调查。结果 身高 (cm )1 0 8.2 7± 7.8;体重 (kg) 8.2 8± 2 .9;Hb 1 2 2 .2± 6 .2 (g/L ) ;ZPP 0 .71± 0 .1 9μmol/L ;ZPP 5 0 %百分位数为 0 .5μm ol/L ;95 %百分位数为 1 .0 6μmol/L ;lg ZPP为 0 .1 1± 0 .0 2μm ol/L、样本特征单因素方差分析 lg ZPP与儿童年龄 (P=0 .0 0 3)及与钢铁厂中心距离 (P=0 .0 33)明显相关 (95 % CI=0 .1～ 0 .1 4 ) ,ZPP水平随年龄增长呈下降趋势。回归分析显示 lg ZPP与 BMI有关。结论 年龄和 BMI是

Objective To explore zinc protoporphyrin (ZPP) level and distribution in children.Methods 335 children (3～7 of age) were investigated in a industry district in Wuhan. Social factors were considered such as sex, age, birthday, parent's occupation and education, lifestyle, body mass index (BMI) and calculated using weight/height. Blood samples were examined for ZPP concentration and hemoglobin (Hb).Results The population consisted of 187 male and 148 female children, height (mean±SD) 108.27±0.8(cm), weight 18.28±3.2(kg), lgZPP 0.11±0.02μmol/L, ZPP 0.71±0.19μmol/L, Hb 122.2±6.2(g/L), ZPP50% percentile is 0.5,95% is 0.83.One way analysis of covariates (ANOVA) shows that lgZPP is significantly associated with age (P=0.03), distance from the steel factory(P=0.033), regression equation is lgZPP=0.629+0.052x 1(BMI)-0.048x 2(age)-x 3(sex).Conclusions BMI?age and sex are risk factors for ZPP.