婴儿肝炎综合征血清免疫球蛋白、补体和一氧化氮水平的探讨

Studying the Lever of IgG, IgA, IgM, C3, C4 and NO in Serum of Infancy Hepatitis Syndrome

目的 测量婴儿肝炎综合征患儿急性期和恢复期血清免疫球蛋白 G(Ig G)、免疫球蛋白 A(Ig A)、免疫球蛋 M(Ig M)、补体 C3、补体 C4和一氧化氮 (NO)水平 ,以了解各因素的变化及其相互关系以及与疾病进展的关系。方法 Ig G、Ig A、Ig M、C3、C4速率散射比浊法。NO终点法。结果 急性期婴肝患儿血清中 Ig G,Ig A及 C3含量显著降低 ,NO水平显著升高 ;恢复期和急性期相比 ,患儿血清中 Ig G、Ig M、Ig A、C3各指标均有所升高 ,但除 Ig M外各指标均较正常对照低 ;NO有所下降但仍高于正常对照。在疾病变化过程中Ig G、Ig M、Ig A的下降与 NO的升高呈负相关 (P<0 .0 5 )。C4无显著性变化。结论

Objective Measuring the level of IgG, IgA, IgM, C3, C4 and NO to recognise the change and find the relationship with one another.Methods Using velocity scatter colorimetry to measure the level of IgG, IgA, IgM, C3, C4 and end point method to test NO.Results The level of IgG, IgA, IgM, C3 in the recovered children had some improvement as compared with the acute children, but it was still lower than the level of normal control except IgM. The concentration of NO in the recovered children had some descending as compared with the acute children, but was also higher than the level of normal control. The concentration of NO negative correlation with the level of IgG, IgA, IgM in the process of infancy hepatitis syndrome, (P<0. 01).Conclusion NO joined the process of infancy hepatitis syndrome and played an important role in immune response.