肾母细胞瘤组织中β-连环素和MMP-7的表达

Expression of β-catenin and MMP-7 in nephroblastoma and its correlation to the invasion and metastasis

目的:探讨肾母细胞瘤组织中β-连环素(β-catenin)和基质金属蛋白酶-7(matrix metalloproteinase-7,MMP-7)的表达及与分化、浸润和转移的关系。方法:应用免疫组化SP法检测30例肾母细胞瘤组织中β-连环素和MMP-7的表达,并与对照组(6例瘤旁正常组织,9例非肿瘤切除的肾组织)相比较。结果:对照组中无β-连环素异常表达,MMP-7不表达,β-连环素和MMP-7在肾母细胞瘤组织中的阳性表达率分别为(41.22±17.06)％和(54.21±10.92)％,在不同组织学分型中差异均有统计学意义,直线相关分析显示2者存在正相关关系(P<0.05,r=0.409)。结论:β-连环素和MMP-7的表达与肾母细胞瘤的浸润和转移密切相关,可作为判断患者预后的重要临床指标。

Aim: To evaluate the expressions of β-catenin and MMP-7 in nephroblastoma and their correlation with the, differentiation,invasion and metastasis. Methods: The expressions of p-catenin and MMP-7 were studied in 30 cases of nephroblastoma by immunohistochemistry. Results: The positive expression rates of β-catenin and MMP-7 were (41. 22 ± 17. 06)% and(54. 21 ±10.92)% respectively. There were significant statistic differences between the expressions and different histologic types(P <0. 05, r =0. 409). A positive correlation was certified between p-catenin and MMP-7 by linear correlation analysis. Conclusion: The expressions of p-catenin and MMP-7 are closely related to the differentiation,invasion and metastasis. Both p-catenin and MMP-7 can be important clinical parameters for judging prognosis of nephroblastoma.