摘要
目的 探讨13 C 美沙西丁呼气试验联合血清胰岛素样生长因子 1(insulinlikegrowthfactor 1,IGF 1)、胰岛素样生长因子结合蛋白。 3 (insulin likegrowthfactorbindingprotein 3 ,IGFBP 3 )测定对肝硬化患者肝功能状况评估的临床意义。方法 随机选取肝炎后肝硬化 14例 ,隔夜空腹 ,服用13 C 美沙西丁 75mg后 ,通过13 C红外线能谱分析仪检测 10个时间段呼出碳 13的含量 ,得出Mvmax40 ( 4 0分钟前13 C代谢速率峰值与正常值的比值 )、CUM 40 ( 4 0分钟13 CO2 累积呼出丰度与正常值的比值 )及CUM 12 0 ( 12 0分钟13 CO2累积呼出丰度与正常值的比值 ) ,并同步采用免疫放射法定量测定血清IGF 1、IGFBP 3水平。结果 肝硬化患者Mvmax 40、CUM 40、CUM 12 0值 ,在ChildA、B、C各组间 ,除A组与B组的CUM 12 0值外 ,差异有显著性 (P <0 .0 5 )。IGF 1,IGFBP 3值在ChildA、B、C组间除ChildA组与B组间外 ,差异有显著性 (P <0 .0 5 )。13 CMvmax 40、CUM 40、CUM 12 0及IGF 1、IGFBP 3值与Childpugh积分呈明显负相关 (r =-0 .881,-0 .878,-0 .83 3 ,-0 .70 0 ,-0 .815 ) ,13 CMvmax 40、CUM 40、CUM 12 0值与IGF 1、IGFBP 3值呈明显正相关。结论 13
Objective To investigate the significance of united determillaLk liver function using 13C-methacetin breath test and insulin-like growth factor-1 (IGF-1),insulin-like growth factor binding protein-3 (IGFBP-3) in liver cirrhosis. Methods Fourteen patients with liver cirrhosis after hepatitis B were enrolled. After oral administration of 13C-methacetin(75 mg),enrichment of breath 13CO 2 of patients were measured by isotope ration infared spectroscopy and 13C Mvmax 40,CUM 40,CUM 120 were gotten.At the same time,IGF-1 and IGFBP-3 were detected.Results the difference of 13C Mvmax 40,CUM 40 among Child-pugh A,B and C groups is notable (P<0.05),and the difference of CUM 120 is very notable between Child-pugh A or B and C group (P<0.01).The difference of IGF-1 and IGFBP-3 of patients among child A,B and C groups is notable (P<0.05)except between child A and B group. 13C Mvmax 40,CUM 40 or CUM 120 and IGF-1 and IGFBP-3 of patients were negative correlative with Child-pugh score(r=-0.881,-0.878,-0.833,-0.700,-0.815). 13C Mvmax 40,CUM 40 and CUM 120 of patients had postive correlation with IGF-1 and IGFBP-3.Conclusion The result show that 13C-Methacetin-breath test could act as a marker that could be used to measure immediate reserve liver function and compensate liver funtion,and could act as clinical complement with IGF-1 and IGFBP-3.
出处
《胃肠病学和肝病学杂志》
CAS
2004年第2期175-178,共4页
Chinese Journal of Gastroenterology and Hepatology