充血性心力衰竭对人体安替比林处置的影响

ANTIPYRINE DISPOSITION IN PATIENTS WITH CONGESTIVE HEART FAILURE

本文对60例正常人和53例充血性心力衰竭患者体内安替比林处置进行了研究。利用高效液相色谱法测定正常人和心衰患者血浆安替比林浓度。根据DΦssing一次样本测定安替比林清除率的方法计算安替比林半衰期及清除率,同时进行心功能测定。11例心衰患者进行了治疗前后血浆安替比林浓度测定。结果表明:正常人组安替比林半衰期15.3±3.2h,清除率25.7±3.81ml/min;心衰组安替比林半衰期29±8.6h清除率12.8±3ml/min。心衰患者的安替比林半衰期和清除率与正常人比较有极显著差异(p<0.001)心衰患者安替比林清除较正常人明显减慢。心衰程度愈重,安替比林清除愈慢。且与心功能指标CO,TPR,肝功能A/G场比值显著相关。提示心衰患者体内安替比林处置存在明显障碍。表明心衰时肝脏药物氧化功能降低。

Antipyrine(AP) disposition was studied in 53 patients with congestive heart fail-ure (CHF) and 60 healthy subjects. plasma levels of AP were measured by HPLC assay. APt 1/2 andCL_(AP)were calculated according to Dφssing's method, Heart function was measured in 41 petients withCHE. Plasma levels of AP were also measured in patients before and after treatment. The resultsshowed that APt1/2 was 15.3±3.2h and CL_(AP) 25.7±3.8ml/min in healthy subjects while in pa-tients with CHF. APt1/2 was 29±8.6h and CL_(AP) 12.8±3ml/min AP disposition was significantlyslower in potients with CHF than in healthy subjects (p<0.001). The more severe the heart failurewas, the slower was the AP disposition. The AP disposition in patients with CHF was also significantlycorrelated with the cardiac output, cardiac index total peripheral resistance and albumin/globulin ra- tio. These results suggest that AP disposition can be altered in patients with CHF. The AP dispositionas a test to determine quantitatively the effect of individual factors on hepatic drug-metabolizing capac-ity could act as an objective index to reflect the damage of liver parenchyma in patients with CHF.