杏仁核毁损对甲基苯丙胺大鼠刻板行为和额叶皮质多巴胺的影响

The effect of nucleus amygdalae lesion on behavior and dopamine content in cortex of frontal lobe in rats.

目的 探讨立体定向杏仁核毁损对甲基苯丙胺 (methamphetamine ,MAP)大鼠刻板行为和额叶皮质多巴胺 (dopamine ,DA)含量的影响。方法 立体定向射频毁损杏仁核 ,经腹腔注射MAP观察大鼠行为学改变 ,荧光分光光度法测定额叶皮质DA含量。结果 杏仁核毁损组大鼠较假手术组大鼠刻板行为评分显著降低 ;甲基苯丙胺逆耐受持续时间显著缩短 ,潜伏期显著延长。MAP大鼠额叶皮质DA含量显著高于对照组 ;杏仁核毁损组的MAP大鼠额叶皮质DA含量显著低于假毁损组。结论 杏仁核毁损可有效地对抗使用甲基苯丙胺而出现的逆耐受现象 。

Objective To explore the effect of nucleus amygdalae lesion using stereotactic technique on contra tolerance of MAP and dopamine level in cortex of frontal lobe in rats. Methods The nucleus amygdalae were destructed by radio frequency(RF) using stereotactic technique. Dopamine level were detected with fluorospectrophotometry. Results The stereotyped behavior score in lesion bundle rats group was significantly lower, the last time of MAP contratolerance was shorter, and the latency was longer respectively than that in pseudo lesion bundle rats group. RF lesion of nucleus amygdalae could reduced content of dopamine in frontal lobe of cortex and showed reduction of stereotyped behavior and could ameliorate symptom of schizophrenia rats. Conclusions Lesion of nucleus amygdalae can block contratolerance phenomenon and reduce DA contents in frontal lobe of cortex.