可降解生物活性颈椎椎间融合器的研制与评价

Fabrication and evaluation of biomaterial fusion cage of cervical vertebrae

目的 用羟基磷灰石 (HAp) /左旋聚乳酸 (PLLA)复合材料研制可降解颈椎椎间融合器。方法 采用化学共沉淀法和开环聚合法制备HAp和PLLA ,按 35 / 6 5重量比共混 ,热压模铸加工成颈椎椎间融合器 ,测试样件的基本理化性质和力学特征 ,并评价初步的临床应用效果。结果 HAp/PLLA复合材料的密度为 1.6 4 g/cm3,热压后粘均分子量为 118.30 9KDa,融合器样件的平均极限压缩强度为 12 8MPa ,E模量 5 .4 7GPa。结论 HAp/PLLA复合材料是一种化学性能稳定、机械性能良好的生物活性材料 ,用其制作的颈椎椎间融合器能够满足颈椎椎间支撑融合的基本要求 ,有希望达到临床上的推广和应用。

Objective To fabracate and study the cervical intervertebral fusion cage with poly-L-lactide and hydroxyapatite.Methods We prepared HAp ultramicroparticles and PLLA by chemical codeposition and open-loop polymerization respectively, blended them in the ratio of 35 to 65 by weight. Being heated and pressed in a mould, the composition was machined into samples of cervical intervertebral fusion cage whose physical and chemical characteristics were examined and whose clinic effect was evaluated initially.Results The average molecular weight of the composition heated and pressed is 118.309 KDa, the densityis 1.64g/cm3.The average compressive strength of cages is 128MPa, and the elastic modular is 5.47GPa.Conclusion The chemical stability and mechanical characters of composition of HAp/PLLA are all good, the cages we made can be satisfactory with its supporting and fusing functions of cervical spine.