TGF—β_1对CD_4^-CD_8^-胸腺淋巴细胞的影响

Transforming growth factor type beta(TGF—β1 )can increase IL—2R expression and suppress the proliferation of immature(CD^(4-)CD^(8-))thymocytes

TGF—β_1是一种对多种细胞的增殖与分化具有重要作用的多肽,它能通过抑制细胞的增殖而发挥调节免疫作用,其机理目前尚不清楚。本文研究 TGF—β_1对 DN 细胞 IL-2R 表达及其细胞增殖的影响,结果发现 TGF—β_1能增加 DN 细胞 IL—2R 的表达和抑 DN 细胞的增殖。

Transforming growth factor type β1(TGF—β1)belong to a family of polypeptides with regulato- ry effects on growth and differention of a variety of cells types.TGF—β1 play an important role in regulation of immune response by acting as a negative modulate the cell proliferation through still unknow mechanisms.We investigated the effect of TGF—β1 on the IL—2R expression and proliferation activited DN cells and we observed that TGF—β1 was able to increase the expres- sion of IL—2R in DN cells and to suppress the proliferation of DN cells and we have discussed about these results.