Gwe对环磷酰胺诱变的对抗效应

Inhibitory effect of Gwe on mutagenesis induced by Cyclophosphomide

Gwe 是一种来自中药的免疫调节剂.实验证明,它能明显抑制由环磷酰胺引起的骨髓细胞微核的形成,减少脾细胞染色体畸变的发生,降低脾细胞姊妹染色单体互换频率,同时能够降低由环磷酰胺引起的 IL—6生成的增高.

Gwe is a new immunological response modifier extracted from a traditional Chinese drug.In our experiments,we demonstrated that:1.Gwe could significantely inhibite micronucleus fre-quencies in bone marrow cells of mice and decrease both the chromosomal aberrations(CA)andsister—chromatid exchange freqencies of splenocytes in mice induced by Cy;2.it could decreasethe activities of IL—6 like substance of splenocytes in mice induced by CY;3.there was a posi-tive correlation between IL—6 activities in the supernatant from cultured spleen cells and mi-cronucleus frequences in bone marrow cells or CA frequences in spleen cells.