复方丹参配伍比例对丹参化学成分溶出的影响

Influence of Compatibility Ratio of Fufang Danshen on the Dissolution of Danshen Compositions

采用高效液相色谱峰比值法比较了由丹参和三七组成的复方丹参中丹参与三七的比例(以质量比计)从10∶0变化到1∶10的过程中丹参化学成分的变化。结果表明:所有合煎样品中丹参的主要成分含量均比单味药丹参中丹参主要成分的含量高,并且经典方(m(丹参)∶m(三七)=5∶3)中丹参主要成分的含量最高。因此,丹参与三七以一定的比例(5∶3)配伍并且采用合煎的方法能够增加丹参成分的溶出率,由此看来中医药中讲究的配伍规律是有其内在的科学道理的。

A high performance liquid chromatographic (HPLC) method has been developed (using) peak ratio to compare the Danshen ingredients with varying peak ratios of Danshen (Salvia miltiorrhiza Bunge.) to Sanqi (Panax Notoginseng) from 10∶0 to 1∶10 in Fufang Danshen which is composed of Danshen and Sanqi. The experimental results show that the contents of major components of all samples decocted together are higher than those of Danshen. The contents of Danshen major components are the highest in classic formula (the mass ratio of Danshen to Sanqi is (5∶3)). Therefore, Danshen decocted together with Sanqi at a ratio of 5∶3 can increase the dissolution ability of Danshen ingredients. This, therefore, could constitute a solid rationale to the compatibility rule in Chinese traditional medicine with both scientific merits and intrinsic reasoning.