南海肉芝软珊瑚中的次生代谢产物分析

Studies on the Secondary Metabolites of the Soft Coral Sarcophyton sp

从采自海南岛三亚湾的一种肉芝软珊瑚Sarcophytonsp 中分离到1个新的对苯二甲酸二酯衍生物 ,通过波谱方法和化学转变测定其结构为对苯二甲酸_1_异丁基_4_(2′_乙基_正己基 )_二酯(1) ;另外 ,还分离鉴定得2个多羟基甾醇 ,24α_甲基_胆甾_5(6)_烯_3β,7α_二醇(2) ,24_亚甲基_胆甾_3β,5α,6β_三醇(3)和α_十六酸_鲨肝醇酯(4) ;化合物2和3对肿瘤细胞有明显抑制作用 ,4具有升白血球作用。

Four secondary metabolites were isolated from the soft coral Sarcophyton sp, collected from Sanya Bay, Hainan Province. Their chemical structures were identified by spectroscopic methods and chemical conversion as 1-isobutyl-4-(2′-ethyl-n-hexyl)-terephthalate(1), 24α-methylcholest-5-en _ 3β,7α-diol(2), 24-methylenecholesta-3β,5α,6β-triol(3), batyl α _ palmitate(4). 2 and 3 show potent growth inhibition for the P388 tumor cells in vitro, whereas 4 has some impact on leukocytosis.