瑞芬太尼复合异丙酚与芬太尼复合异丙酚用于无痛人流的比较分析

A Comparative Analysis of Combined Emifentanil Propofol and Combined Fentanyl Propofol in Painless Induced Abortion

目的 :比较瑞芬太尼复合异丙酚与芬太尼复合异丙酚用于无痛人流的临床效果。方法 :1 0 0例要求终止妊娠的早孕妇女随机分成芬太尼组 (A组 ,5 0例 )和瑞芬太尼组 (B组 ,5 0例 ) ,两组均先分别静注芬太尼、瑞芬太尼后静注异丙酚 1 .5mg/kg诱导 ,A组静注芬太尼 0 .0 5mg ,B组静注瑞芬太尼 0 .0 5mg ,术中静脉追加异丙酚 0 .5mg/kg ,观察SpO2 、HR、MAP变化、异丙酚总用量、镇痛效果。结果 :术中异丙酚追加量和总用药量A组显著高于B组 (P <0 .0 5 ) ,苏醒时间A组显著长于B组。呼吸循环的变化两组间无显著差异。结论 :瑞芬太尼较芬太尼用于无痛人流具有药效、安全相似 ,但镇痛强 ,苏醒较快、镇痛效果满意等优点 ,值得推广应用。

Objective:Comparison between Remifentanil and Fentany combined respectively with propofol for painless induced abortion in clinical effect.Methods:100 women with early pregnant were randomly grouped into fentany(A group,50 cases) and remifentany (B group,50 cases).Both groups employed intravenously fentany or remifentany,then propofol 2mg/kg for inducing.Fentany was used for A group in 0.05mg,remifentany for B group in 0.05mg,and propofol was superadded intravenously in 0.5mg in the courses.SpO 2、HR、MAP change.propofoltotal usage and analgesic efficacy were observed.Results:The number of superaddition and total usage of Group A was extraordinarily higher than Group B,and the duration of wake quite was longer than Group B.The variety of respiration and circulation between the two groups was not significantly different.Conclusion:Both remifentany and fentany are similar in efficacy and safety,but the former is more effective in analgesia and the patients will wake sooner.It is worthy to be suggested to be used widely.