摘要
目的探讨CD44v6在胃癌发展、转移中的作用。方法采用逆转录-聚合酶链反应(RT-PCR)方法检测64例胃癌患者胃癌及其正常胃黏膜CD44v6mRNA表达。结果胃癌患者胃的正常黏膜有少量CD44v6mRNA表达;;胃癌组织CD44v6mRNA的表达阳性率高于其正常黏膜。胃癌组织CD44v6mRNA表达阳性率在淋巴结转移患者(75.56%)高于无淋巴结转移者(36.84%),有远处转移者(92.86%)高于无远处转移组(41.87%),患者性别、肿瘤长径<5cm与≥5cm、肿瘤发生部位、大体类型、组织类型、组织学分化程度、浸润深度和TNM分期与CD44v6表达阳性率无关。结论胃的正常黏膜有少量CD44v6表达,胃癌组织CD44v6表达明显增多,CD44v6表达较多提示淋巴结转移和远处转移的可能。
Objective To investigate the expression of CD44 variant 6 (CD44 v6) mRNA in human gastric cancer. Methods CD44v6 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR) in specimens of cancer tissue and normal gastric mucosa from 64 patients with gastric cancer. Results The expression of CD44 v6 mRNA was significantly higher in gastric cancer tissue than that in normal mucosa. The expression of CD44v6 mRNA was higher in cancer patients with lymph node and distant metastasis compared with those without metastasis. Conclusion The CD44v6 expression is significantly higher in gastric cancer than in normal tissue and is associated to lymph node involvement and distant metastasis.
出处
《浙江医学》
CAS
2004年第3期184-186,共3页
Zhejiang Medical Journal
基金
卫生部科学研究基金资助(D39901)
