中毒导致急性呼吸窘迫综合征13例分析

Analyais on 13 Cases of Acute Respiratory Diatreas Syndrome Reaulting from Poiaoning

目的:探讨各种中毒导致急性呼吸窘迫综合征(ARDS)的病因、治疗、预后。方法:分析1998年10月～2002年10月4年间13例ARDS的临床资料。结果:(1)13例ARDS占中毒病例的0.68%;(2)百草枯、有机磷和一氧化碳中毒导致ARDS发生率较高;(3)2例百草枯和2例一氧化碳中毒表现为单相速发型,其余9例表现为双相迟发型,均合并4个以上脏器损伤;(4)所有病例均予祛毒加综合治疗。(5)发生ARDS的死亡率高,与未发生ARDS的中毒而有MODS的中毒比较有显著性差异(P<0.01)。结论:以祛除毒源和综合治疗为主,可改善ARDS患者预后。

Objective: To investigate the cause, therapy and prognosis of acute respiratory distress syndrome (ARDS) resulting from a variety of poisoning. Methods:The clinical data of 13 patients with ARDS in four years,(from October 1998 to October 2002),were analysed. Results:There were 0. 68% of poisoning intoxication in 13 patients. The morbidity of paraquat, organophosphours and carbon monoxide were higher than others. Two patients with paraquat and 2 patients with carbon monoxide manifested as anticipated monophasic type,and 9 others patients as delayed diphasic type,with more than four organs injury. Poison was dispelled adding integrative therapy for all patients. The mortality of patients with ARDS was higher in comparison with MODS( P < 0. 01). Conclusion: It could improve the prognosis of ARDS with dispelling poisoning adding inlegrative therapy.