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E—Cadherin在人肝细胞癌中的表达及其意义 被引量:1

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摘要 目的 探讨上皮型钙依赖粘附蛋白(E—Cadherin,E—cad)在人肝细胞癌中的表达及其意义。方法 应用免疫组化技术检测59例人肝细胞癌及其相应癌旁组织中E—cad蛋白的表达。结果 所有病例癌旁组织中E—cad均呈强阳性表达,而肝癌组织E—cad表达明显减低甚或缺失,且E—cad异常表达率在肝癌肿瘤大小、组织学分级、临床分期、侵袭转移能力及术后生存期等方面具有显著差异(P<0.05)。结论 E—cad表达异常与肝细胞痛的恶性生物学行为密切相关,可作为判断肝癌预后的一个有用指标。
出处 《中华医学研究与实践》 2004年第3期3-5,共3页
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