配体—受体系统介导的药物靶向性研究进展

Progress in Ligand-Receptor System Mediated Drug Targeting

配体 受体系统介导的药物靶向性研究在过去 10年中得到了很大的发展。配体介导的主动靶向能够将药物定向运送到血管腔隙、细胞表面和细胞内。使用的配体包括抗体、蛋白质、肽、脂蛋白、糖类以及其他内源性分子。文章介绍了药物靶向研究中使用的多种配体 受体系统 ,包括运铁蛋白受体、脂蛋白受体、细胞因子受体、凝集素受体、清道夫受体和叶酸受体。

The rapid progress in has developed in past decade. ligand-receptor system mediated drug targeting. Ligand mediated active targeting has been shown to be a novel method in targeting vascular compartment, cellular or intracellular levels. The common ligands include antibodies, proteins, Peptides, lipoproteins, carbohydrates, and endogenous molecules. This review describe various ligand-receptor systems that have been investigated for drug targeting. These receptors are transferrin receptors, lipoprotein receptors, cytokine receptors, lectin receptors, scavenger receptors, and folate receptors.