滋肾化瘀方治疗大鼠系膜增生性肾小球肾炎的药理研究

Pharmacological Study on "Zishen Huayu Fang" on Treatment of Mesangial Proliferative Glomerulonephritis in Rats

目的 :探讨滋肾化瘀方对系膜增生性肾小球肾炎大鼠的治疗作用及其作用机理。方法 :用尾静脉注射抗胸腺细胞血清诱发系膜增生性肾小球肾炎大鼠模型 ,经滋肾化瘀方治疗后 ,观察滋肾化瘀方对模型大鼠肾功能及肾组织形态学的影响。结果 :滋肾化瘀方能显著降低模型组大鼠尿蛋白及尿红细胞含量、血清尿素氨 (BUN)、肌酐 (Scr)水平 ;提高血清白蛋白含量 ;减少肾小球毛细血管上皮下IgG、C3 免疫复合物沉积 ,使肾小球病理损害减轻。结论 :滋肾化瘀方能减轻模型大鼠肾小球及基质病变 。

Objective:To explore the effects and the mechanisms of 'Zishen Huayu Fang' (ZSHYF) on treatment of mesangial proliferative glomerulonephritis (MPG) in rats Methods:The rat model of MPG was induced by injecting anti thymocyte serum (ATS) through caudal vein The effects of ZSHYF on renal function and morphology were studied Results:ZSHYF can remarkably reduce urine protein,urine red blood cell and serum levels of BUN and Scr,increase serum albumin content,decrease immune complex IgG and C 3 under epithelial cells of glomerulus capillary and alleviate the pathological injury in MPG rats. Conclusions:ZSHYF can lessen pathological changes of glomerulus and stramo in MPG rats, stabilize and ameliorate their renal function