决明子抑制营养性肥胖大鼠体重增加的作用

Inhibitive Effect of Semen Cassiae on the Weight Gain in Rats with Nutritive Obesity

目的 :观察大鼠生理状态下自然饮用决明子水煎剂对营养性肥胖体重的影响 ,并初步探讨其作用机理。方法 :用高营养饲料制造肥胖大鼠模型 ,让大鼠在生理状态下自然饮用不同浓度的决明子水煎剂 ,观察其对大鼠体重和糖、脂代谢及抗脂质过氧化作用的影响。结果 :6 %浓度的决明子水煎剂可明显降低营养性肥胖大鼠的体重、Lee’s指数、空腹血清甘油三酯、胰岛素和丙二醛含量 ,游离脂肪酸含量也有下降趋势 ,总抗氧化能力水平有升高趋势。结论 :决明子水煎剂能明显抑制营养性肥胖大鼠体重的增加 。

Objective: To observe the effect of water extract of Semen Cassiae on the weight gain of nutritive obesity rat. Methods:Nutritive obesity model in rats was made by high nutritive diet. Various concentration water extracts of Semen Cassiae were drunk by the rats at physiological state. Weight,metabolism of glucose and lipids,and anti lipid peroxidation of rats were observed Results: 6% concentration water extract of Semen Cassiae could significantly reduce the weight and Lee's index,lower the fasting serum levels of triglyceride,insulin and malondialdehyde(MDA). Conclusions: Water extract of Semen Cassiae could significantly inhibit the weight gain of high nutriment fed rats. The mechanism might be related with its metabolism regulating actions on glucose and lipids