趋化因子受体与HIV感染
Chemokine receptors and humam immunodeficiency virus infection
摘要
近年有关人免疫缺陷病毒-1(HIV-1)的研究表明,趋化因子受体及其配体在HIV侵入靶细胞过程中起重要作用,多种趋化因子和细胞因子可以阻断和/或调节趋化因子受体。同时,以靶细胞表面的趋化因子受体为靶点的调控、治疗HIV感染的新方法已成为国内外研究的热点,本文对这一方面的研究进展作了综述。
参考文献19
-
1Feng Y, Christopher C, Broder PE, et al. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science, 1996,272(5263): 872-879.
-
2Venkateson S, Petrovic A, Van Ryk DL, et al. Reduced cell surface expression of CCR5 in CCR5 delta 32 heterozygotes is mediated by gene dosage, rather than receptor sequestration. J Biol Chem, 2002, 277(3):2287-2301.
-
3Sandrina MI, Kapylov VM, Miloserdova OV, et al. Analysis of the 32bp deletien im the CCR5 chemokine receptor gene in people from Moscow,infected with HIV-1. Genetika, 2001, 36(5): 718-720.
-
4Moss RB, Giermakowska WK, Diveley JP, et al. CXCR4 and CCR5 expression on CD4+ T cells in vivo and HIV-1 antigen beta-chemokine production in vitro after treatment with HIV-1 immunogen. J Hum Virol,2000,3( 1 ): 44-49.
-
5Bailer RT, Lee B, Montaner LJ, et al. IL-13 and TNF-alpha inhibit dualtropic HIV-1 in primary macrophages by reduction of surface expression of CD4, chemokine receptors CCR5, CXCR4 and post-entry viral gene expression. Eur J Immunol, 2000, 30(5): 1340-1349.
-
6Verani A, Siroui F, Siccardi AG, et al. Inhibition of CXCR4-tropic HIV-1 infection by lipopolysaccharide evidence of different mechanisms in macrophages and T lymphocytes. J Immunol, 2002, 168 (12): 6388-6395.
-
7Jourdan P, Vendrell JP, Huguet MF, et al. Cytokines and cell surface molecules independently induce CXCR4 expression on CD4 CCR7 human memory T cells. J Immunol,2000,165(2): 716-724.
-
8Losana G, Bovolenta C, Rigamouti L, et al. IFN-gemma and IL-12 differentially regulate C-C chemokine secretion and CCR5 expression in human T lymphocytes. J Leukoc Bid, 2002,72(4): 735-742.
-
9Vicezi E, Panina-Bodignon P, Vallanti G, et al. Restricted replication of primary HIV-1 isolated using botyh CCR5 and CXCR4 in TH2 but not in TH1 CD4+ T cells. J Leukoc Biol, 2002,72(5): 913-920.
-
10Estes JD, Kcele BF, Tenner-Racz K, et al. Follicular dendritic cellmediated upregulation of CXCR4 expression on CD4+ T cells and HIV pathogenesis. J Immunol, 2002, 169(5): 2313-2322.
-
1孙杰.人免疫缺陷病毒-1感染妇女哺乳对死亡率的影响[J].国外医学（内科学分册）,2003,30(4):175-175.
-
2沈成利,吴昊.急性HIV-1感染的传播和预防[J].国外医学（流行病学．传染病学分册）,2004,31(2):71-73.
-
3赵一平,毛东伟.防治艾滋病有效、廉价的方法[J].中国卫生经济,2002,21(3):23-23. 被引量：1
-
4张洪涛.人免疫缺陷病毒-1型疫苗研制的策略[J].国外医学（输血及血液学分册）,1999,22(5):328-331.
-
5孙杰.美国三藩市注射毒品者人免疫缺陷病毒——1性传播的危险因素分析[J].国外医学（内科学分册）,2003,30(4):175-176.
-
6王典,康祥锦,谢庆东,黄天华.人免疫缺陷病毒-1 gag基因在人成熟精子中的表达[J].癌变．畸变．突变,2010,22(6):455-457.
-
7王琪,尚红,姜拥军,王亚男,张子宁,刁莹莹,刘静,张民,韩晓旭.中国HIV感染者细胞毒性淋巴细胞内穿孔素的差异性表达[J].中华微生物学和免疫学杂志,2006,26(3):258-262. 被引量：2
-
8陈应华,肖翌,P.D.Manfred.HIV-1侵入靶细胞的机理[J].自然科学进展（国家重点实验室通讯）,2000,10(2):97-101.
-
9肖苏龙.人免疫缺陷病毒-1整合酶及其抑制剂的研究进展[J].国外医学（药学分册）,2002,29(3):157-161. 被引量：6
-
10徐东兵,韩晓旭,张子宁,张旻,代娣,赵彬,王亚男,张晓丽,包名家,尚红.中国HIV-1感染者K／R基因多态性与疾病进展关系的研究[J].中华微生物学和免疫学杂志,2008,28(12):1099-1102. 被引量：4
