丙型肝炎病毒体外复制及其动物模型
The replication in vitro of hepatitis C virus and the animals available for its infection
摘要
本文简要介绍了丙型肝炎病毒在肝细胞系和淋巴细胞系中的复制情况,着重介绍了丙型肝炎病毒复制子在HuH-7细胞中的复制规律;阐述了黑猩猩、转基因小鼠和嵌合肝脏小鼠作为丙型肝炎病毒研究的动物模型所存在的优缺点,以及树鼩作为丙型肝炎病毒研究的动物模型的可能性。
参考文献22
-
1Koff RS. Hepatitis vaccines: recent advances. lnt J Parasitol, 2003,33: 517 ～ 523.
-
2Carloni G, Iacovacci S, Sargiacomo M, et al. Susceptibility of human liver cell cultures to hepatitis C virus infection. Arch Virol Suppl, 1993,8: 31-39.
-
3Kato N, lkeda M, Mizutani T, et al. Replication of hepatitis C virus in cultured non-neoplastic human hepatocytes. Jpn J Cancer Res, 1996,87:787-792.
-
4Seipp S, Mueller HM, Pfaff E, et al. Establishment of persistent hepatitis C virus infection and replication in vitro. J Gen Virol, 1997, 78:2467-2476.
-
5Shimizu YK, Purcell RH, Yoshikura H. Correlation between the infectivity of hepatitis C virus in vivo and its infectivity in vitro. Proc Nail Acad Sci USA, 1993, 90:6037-6041.
-
6Shimizu YK, Feinstone SM, Kohara M, et al. Hepatitis C virus: detection of intracellular virus particles by electron microscopy. Hepatology,1996, 23:205-209.
-
7Chung RT, He W, Saquib A, et al. Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system.Proc Natl Acad Sci USA, 2001, 98:9847-9852.
-
8Pietsckmann T, Lohmann V, Kaul A, et al. Persistent and transient replication of full-length hepatitis C virus genomes in cell culture.J Virol, 2002, 76: 4008-4021.
-
9Lohmann V, Komer F, Koch J, et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science, 1999, 285:110-113.
-
10Blight KJ, Kolykhalov AA, Rice CM. Efficient initiation of HCV RNA replication in cell culture. Science, 2000, 290: 1972-1974.
-
1王联群,刘德伍.表皮干细胞增殖分化的调控机制[J].中国组织工程研究与临床康复,2008,12(47):9343-9346. 被引量：1
-
2陈杰斌,许从峰,陈瑞珍,虞勇,李丽,杜九中,郭棋,杨英珍,邓晖,李双杰.特异性的VP1-siRNA对CVB3复制抑制作用的研究[J].中华微生物学和免疫学杂志,2006,26(7):584-587.
-
3于建国,侯宪荣.庚型肝炎与其病毒研究的进展[J].泰山卫生,1999,23(2):32-34.
-
4陈小平.艾滋病病毒研究的某些进展(三)[J].中国性病艾滋病防治,2000,6(2):121-121.
-
5候金林,王战会,杨洁.基因变异研究技术及其在乙型肝炎病毒研究中的应用[J].解放军医学杂志,1996,21(4):309-313.
-
6金友国.慢性乙型病毒性肝炎的抗病毒治疗进展[J].中国临床药学杂志,2011,20(2):125-128. 被引量：14
-
7虞福亮.丁型肝炎病毒研究的某些进展[J].中华传染病杂志,1990,8(3):161-165.
-
8范燕文.国内外庚型肝炎病毒研究的新进展[J].中国现代医学杂志,1998,8(3):14-16.
-
9刘海燕,宁德刚.庚型肝炎病毒研究若干进展[J].中西医结合肝病杂志,2000,10(5):62-63. 被引量：5
-
10郝崇华,刘建红.乙型肝炎患者前S1抗原检测的临床意义[J].临床医药实践,2005,14(12):928-929.
