摘要
近年来 ,吲哚咔唑类化合物Staurosporine及其衍生物对肿瘤相关酶活性的抑制作用得到了广泛的研究。此类化合物对蛋白激酶C、细胞周期蛋白依赖激酶、检测点激酶等都具有较好的抑制作用 ,并能抑制肿瘤细胞增殖 。
Indolocarbazole compounds, such as staurosporine and its derivatives, as potent kinase inhibitors have been studied comprehensively. Besides inhibiting protein Kinase C very well, they show potential bioactivities against Cyclin dependent kinase and Checkpoint kinase, and cell proliferation. Here a review is given to introduce the recent studies about the antitumor activity of indolocarbazoles by inhibiting kinases relative to cancer [
出处
《药学进展》
CAS
2004年第4期154-158,共5页
Progress in Pharmaceutical Sciences