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吲哚咔唑类化合物对肿瘤相关酶的抑制作用 被引量：2

Indolocarbazoles as Potent Inhibitors of Kinases Relative to Tumor
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摘要 近年来 ,吲哚咔唑类化合物Staurosporine及其衍生物对肿瘤相关酶活性的抑制作用得到了广泛的研究。此类化合物对蛋白激酶C、细胞周期蛋白依赖激酶、检测点激酶等都具有较好的抑制作用 ,并能抑制肿瘤细胞增殖 。 Indolocarbazole compounds, such as staurosporine and its derivatives, as potent kinase inhibitors have been studied comprehensively. Besides inhibiting protein Kinase C very well, they show potential bioactivities against Cyclin dependent kinase and Checkpoint kinase, and cell proliferation. Here a review is given to introduce the recent studies about the antitumor activity of indolocarbazoles by inhibiting kinases relative to cancer [
作者 朱冰 尤启冬 翟富民 李志裕
机构地区 中国药科大学药学院
出处 《药学进展》 CAS 2004年第4期154-158,共5页 Progress in Pharmaceutical Sciences
关键词 吲哚咔唑类化合物 肿瘤相关酶 蛋白激酶C 细胞周期蛋白依赖激酶 检测点激酶 细胞增殖 Indolocarbazole, Tumor, Kinase,Inhibition
分类号 R96 [医药卫生—药理学]
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参考文献18

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同被引文献75

  • 1徐光,张礼萍,陈力芳,胡昌奇.二苯乙烯类化合物对蛋白激酶C的抑制作用[J].药学学报,1994,29(11):818-822. 被引量：20
  • 2徐瑞明,金顺子,刘扬,刘树铮.蛋白激酶PKCθ的研究进展[J].吉林大学学报（医学版）,2005,31(4):640-644. 被引量：10
  • 3易兰兰,徐静.蛋白激酶C和糖尿病肾病[J].医学综述,2006,12(3):154-156. 被引量：9
  • 4白璐璐,唐建武,张众.肺癌中蛋白激酶C-α、βⅡ及δ的表达及意义[J].临床与实验病理学杂志,2006,22(2):186-190. 被引量：7
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药学进展
2004年 第4期

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