玉竹总苷对大鼠血流动力学的影响

Effect of Saponins of Radix Polygonati officinalis on the Hemodynamics in Rats

目的 :观察玉竹总苷 (SaponinsofRadixPolygonatiofficinalis.RPOS)对大鼠血流动力学的影响。方法 :采用Med lab -u/ 8c八道生物信号采集处理系统记录静脉注射RPOS后大鼠血流动力学指标的改变 (LVSP、±dp/dtmax、LVEDP、HR、SAP和DAP)。各组均以给药前各项指标为对照进行统计学处理 ,计算机监视记录结果及分析。结果 :静脉注射RPOS(30 0mg、6 0 0mg、80 0mg·kg-1)后 ,可剂量依赖性地降低麻醉Wistar大鼠的SAP和DAP ,并以降低DAP的作用明显 ;对HR影响不明显 ;LVSP、±dp/dtmax绝对值明显增加 ,而LVEDP下降。结论 :RPOS对麻醉大鼠有降低SAP和DAP的作用 (以DAP降低明显 ) ,对麻醉大鼠心肌具有正性肌力作用 ,并且呈一定的剂量依赖关系。提示其降血压作用可能与降低外周血管阻力有关。

Objective: To observe the effect of saponins of radix polygonati officinalis on the hemodynamics in rats. Methods: The hemodynamics changes were tested with Medlab-u/8c processing system in rats, such as, LVSP, ±dp/dtmax, LVEDP, HR, SAP and DAP. All parameters were compared with the parameters before medication by the statistics analysis of computer. Results: It can descent the SAP and DAP of anesthetic Wistar rats by the injection of vein with saponins of radix polygonati officinalis (300,60,80mg·kg -1 ) in dose-dependence, especially the descent of DAP. It has no distinct effect on HR. The absolute value of LVSP&±dp/dtmax is distinctly increased, with the descent of LVEDP. Conclusion: Saponins of radix polygonati has the effect of decreasing SAP and DAP in the anesthetic rats, and the positive muscle force to rats' myocardium in dose-dependence, which suggest that the effect of decrease the blood pressure could be related to the decreasing of resistance.