胃肠道恶性间质瘤的临床诊治

Clinical diagnosis and treatment of gastrointestinal stromal sarcomas

目的 探讨胃肠道恶性间质瘤的临床诊断与治疗。方法 回顾性分析 1993～ 1999年 2 2例胃肠道恶性间质瘤病人的临床资料。结果 胃部肿瘤 14例 ,小肠肿瘤 8例。其中 5例高度恶性 ,17例低度恶性。 1例广泛转移行肝结节活检 ,术后 4个月死亡。 4例行姑息切除 ,1例复发。其余行根治术 ,无病生存最长达 5年。结论 要提高对胃肠道恶性间质瘤的认识 ,加强免疫组化检查 ,确定良恶性及恶性程度 ,根治性手术对预后及防止复发有一定意义。

Objective To investigate the diagnosis and treatment of gastrointestinal stromal sarcomas. Methods The clinical data of 22 patieats with gastrointestinal stromal sarcomas were reviewed.ResultsOf them,14 tumours originated in the stomach,8 cases were in small bowel; 5 cases were highly malignant,17 in low degree; liver nodal biopsy was done in 1 patient due to diffuse metastatic disease,who died in 4 months after operation;4 patient were resected incompletely ,I of which had recurrence. Complete resection was possible in other patients. ConclusionIt is important to understand the disease;histopathological and immunohistochemical features can help diagnosis in gastrointestinal stromal sarcomas.Treatment involves mainly radical resection which can be curative.