摘要
基于吡哌酸对Ce(Ⅳ) SO2-3化学发光体系有较强的增敏作用,结合流动注射分析技术,提出了吡哌酸的化学发光测定法。方法选择性好、灵敏度高。吡哌酸在1.0×10-7～1.0×10-5g·ml-1浓度范围内与化学发光分析信号呈线性关系,其检出限为4×10-8g·ml-1。对5.0×10-6g·ml-1的吡哌酸进行11次连续测定,相对标准偏差为2.5%。方法已成功地应用于片剂中吡哌酸含量的测定。
Based on the strong sensitivization effect of pipemidic acid on the chemiluminescence (CL) reaction system of Ce(Ⅳ)-SO^(2-)_3, in hyphenation with the flow-injection technique, a new method for the chemiluminescence determination of pipemidic acid is proposed. Linear relationship between the CL signals of the reaction Ce(Ⅳ) with SO^(2-)_3 and the concentrations of pipemidic acid is obtained in the range of 1.0×10^(-7) to 1.0×10^(-5)g of pipemidic acid per ml of solution. RSD′s (n=11) obtained at the concentration level of 5.0×10^(-6)g·ml^(-1) is 2.5% and the detection limit of this method is 4×10^(-8)g·ml^(-1). The specific features of this method are its high sensitivity and good selectivity. This method has been satisfactorily applied to the analysis of drug troche for its pipemidic acid contents.
出处
《理化检验（化学分册）》
CAS
CSCD
北大核心
2004年第4期195-197,共3页
Physical Testing and Chemical Analysis(Part B:Chemical Analysis)
基金
河南省高校青年骨干教师资助计划
