孤独症危险因素的病例对照研究

Case-control study on risk factors of childhood autism

目的探讨孤独症发病的危险因素。方法对符合DSM—IV孤独症诊断标准的儿童孤独症者2 13人与年龄、性别均衡的 13 2名正常对照进行病例对照研究。结果病例组母孕期宫内窘迫 (OR =2 .792 ,95 %CI :1.0 0 2 ,7.782 )、出生窒息 (OR =5 .488,95 %CI :1.2 3 2 ,2 4.44 9)、抽搐病史 (OR =3 .481,95 %CI :1.785 ,6.789)、父亲内向 (OR =6.699,95 %CI:3 .82 0 ,11.747)高于对照组 ;孤独症病例父系家族史比例高于母系家族史。结论母孕期至婴幼儿期的并发症是孤独症的危险因素 ,使该病发病风险提高。孤独症病例父系家族史多见。

ObjectiveTo identify potential risk factors for autism.Methods213 children with autism(DSM-IV criteria) and 132 normal children matched by sex and age were investigated respectively. ResultsThere were significant association between autism and fetal distress(OR=2.792,95%CI:1.002,7.782), neonatorum asphyxia (OR=5.488,95%CI:1.232,24.449),history of seizure(OR=3.481,95%CI:1.785, 6.789),paternal introversion(OR=6.699,95%CI:3.820,11.747).The paternal disease histories of autism patients were much more than the maternal ones.ConclusionsThe unfavorable events in pregnancy, delivery, and the neonatal phase increase the risk of autism.The paternal disease histories of autism patients are common.