山茶花总黄酮对血小板聚集和实验性血栓形成的影响

Effects of total flavone of C on platelet aggregation and experimental thrombosis

目的 研究山茶花总黄酮 (TFC)对血小板聚集和实验性血栓形成的影响。方法 采用体外血小板聚集实验法观察TFC对血小板聚集的影响 ;采用大鼠动静脉血栓旁路法观察TFC对实验性血栓形成的影响。结果 TFC 1 0、0 5、0 2 5 g/L能明显对抗胶原诱导的血小板聚集 ;TFC 6 0、30mg/kg能明显减轻大鼠血栓的湿重。 结论 TFC具有明显的抗血小板聚集、抑制血栓形成的作用。

Objective To study the effects of total flavone of C(TFC) on platelet aggregation and experimental thrombosis. Methods Inhibition rates of platelet aggregation for TFC in vitro were determined by the model of platelet aggregation induced by coll;inhibition rates of experimental thrombosis for TFC were measured by the model of A-V thrombosis passby. Results TFC 1.0,0.5,0.25 g/L had magnificent effect on inhibition of platelet aggregation;TFC 60,30 mg/kg decreased the wet weight of thrombosis obviously compared with the control group. Conclusion TFC exhibits inhibition of platelet aggregation and antithrombosis effects.