莱姆病实验动物模型研究

A Study on Experimental Animal Models of Lyme Disease

用从我国新疆全沟硬蜱分离培养的莱姆病螺旋体(XS3),实验感染了新西兰白兔、大耳白兔、13号鼠、大白鼠、中国地鼠、金黄地鼠和豚鼠等7种动物。在一只新西兰白兔发现慢性游走性红斑,一只金黄地鼠和一只13号鼠产生关节炎。患病动物都有较高滴度的抗体。这些结果证实。(1)我国全沟硬蜱莱姆病螺旋体具有足够致病的能力;(2)经培养传代的螺旋体的毒力是稳定的,可引起实验动物莱姆病;(3)莱姆病的发病机理可能与免疫应答有关。另外,证实血中螺旋体的浓度较低,持续时间较短。

Eleven laboratory animals,including New Zealand white rabbits,giant ear white rabbits.No.13 hamsters,giant white rats,Chinese hamsters,golden Syrian hamsters and cavies were inoculated with cultured spirochetes isolated from Ixodes persulcatus in Xinjiang.Erythema chronic migrating was seen in one New Zealand white rabbit in injecting sties.Lyme arthritis also was confirmed in one golden Syrian hamster and one No.13 hamster.The animals with the disease had higher antibody titers to Borrelia burgdorferi than the others.These finding showed:(1) the spirochetes of our nation were capable of casuing Lyme disease in the laboratory animals; (2) the cultured spirochetes could casue the disease and their virulance was stable; (3) the pathogenesis of Lyme disease was in connexion with immune response.In addition,we also discovered that spirochetal concentration in blood was low and spirochetal duration was short.