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肠内免疫营养对手术创伤患者营养支持效果及对免疫功能的影响

Effect of Postoperative Immunonutrition on Host Nutritional Status and Immunity
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摘要 研究肠内免疫营养和普通肠内营养对腹部手术创伤后患者的不同作用 .40例腹部中等以上手术患者随机分为肠内免疫营养组 (研究组)和普通肠内营养组 (对照组 ) ,分别于术后第2~8d予等热卡 (1 2 5 .4kJ/ (kg·d) )营养支持 .用药期间留 2 4h尿粪定氮 ,于术前 1d和术后 9d测体重、上臂周径及三头肌皮皱厚度 ,术前 1d、术后 5d、术后 9d检测血清总蛋白、白蛋白、前白蛋白、转铁蛋白 ,术前 1d、术后 1d和术后 9d检测血清IgG、IgM、IgA、CD4、CD8、CD4/CD8、白介素 1_α、白介素_2、白介素_6、白介素_1 0、肿瘤坏死因子_α.结果表明 ,经过一周的营养支持 ,与普通肠内营养组相比 ,免疫营养组转铁蛋白、IgA、CD4、CD4/CD8显著增加 ,IgA差值、CD4/CD8差值亦显著增加 .说明肠内免疫营养可有效改善腹部手术创伤后患者营养状况 ,同时可改善患者的免疫功能 。 To evaluate the effect of enteral immunonutrition on host nutritional status and immunity in postoperative patients,a prospective,randomized and controlled trial was performed.Forty patients undergoing abdominal surgery were randomized to receive either immunonutrition or normal nutrition for7days after surgery.The daily nutritional goal was125.4kJ/(kg·d).Nitrogen balance was measured.Weight,mid_arm circumference,skinfold thickness,total albumin,albumin,prealbumin and transferrin were determined as nutritional indicators.Immune responses were investigated by IgG,IgM,IgA,CD4,CD8,CD4/CD8,IL1_α,IL_2,IL_6,IL_10,TNF_α.After a week of nutritional support,in the immunonutrition group,transferrin level,IgA level,CD4and CD4/CD8ratio were higher than those in the control group,and IgA and CD4/CD8recovered more obviously than those in the control group.In conclusion,postoperative administration of immunonutrition in patients can improve nutritional status and enhance patients’immunity.
出处 《南京大学学报(自然科学版)》 CAS CSCD 北大核心 2004年第2期185-191,共7页 Journal of Nanjing University(Natural Science)
关键词 肠内免疫营养 手术创伤患者 营养支持效果 免疫功能 腹部手术 enteral nutrition,immunonutrition,trauma,immunity
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  • 1Bozzetti F, Braga M, Gianotti L, et al. Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer: A randomised multicenter trial. Lancet, 2001, 358(9292) : 1487-1492.
  • 2Braga M, Gianotti L, Gentilini O, et al. Early postoperative enteral nutrition improves gut oxygenation and reduces costs compared with total parenteral nutrition. Critical Care Medicine, 2001, 29 (2):242-248.
  • 3Braga M, Vignali A, Gianotti L, et al. Immune and nutritional effects of early enteral nutrition after major abdominal operations. European Journal of Surgery, 1996, 162(2) : 105-112.
  • 4李宁.临床营养的新概念:免疫营养[J].中国实用外科杂志,2001,21(1):7-9. 被引量:90
  • 5李元新,黎介寿.百普素进行肠内营养支持的疗效观察[J].南京大学学报(自然科学版),1997,33(Z11):154-157. 被引量:4
  • 6Senkal M, Zumtobel V, Bauer K H, et al. Outcome and cost-effectiveness of perioperative enteral immunonutrition in patients undergoing elective upper gastrointestinal tract surgery: A prospective randomized study. Achieves of Surgery, 1999, 134(12) : 1309-1316.
  • 7Gianotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid-, and RNA-enriched enteral diet: Effect on host response andnutritional status. Journal of Parenteral and Enteral Nutrition, 1999, 23(6):314-320.
  • 8Beale R J, Bryg D J, Bihari D J. Immunonutrition in the critically ill: A systematic review of clinical outcome. Critical Care Medicine, 1999, 27(12):2799-2805.
  • 9Efron D, Barbul A. Role of arginine in immunonutrition. Journal of Gastroenterology, 2000, 35 (Suppl12) :20-23.
  • 10Grimm H, Mayer K, Mayser P, et al. Regulatory potential of n-3 fatty acids in immunological and inflammatory processes. British Journal of Nutrition, 2002, 87 (Suppl 1) :S 59-67.

二级参考文献1

  • 1Lieberman M D,Nutrition,1990年,6卷,1期,88页

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