摘要
研究肠内免疫营养和普通肠内营养对腹部手术创伤后患者的不同作用 .40例腹部中等以上手术患者随机分为肠内免疫营养组 (研究组)和普通肠内营养组 (对照组 ) ,分别于术后第2~8d予等热卡 (1 2 5 .4kJ/ (kg·d) )营养支持 .用药期间留 2 4h尿粪定氮 ,于术前 1d和术后 9d测体重、上臂周径及三头肌皮皱厚度 ,术前 1d、术后 5d、术后 9d检测血清总蛋白、白蛋白、前白蛋白、转铁蛋白 ,术前 1d、术后 1d和术后 9d检测血清IgG、IgM、IgA、CD4、CD8、CD4/CD8、白介素 1_α、白介素_2、白介素_6、白介素_1 0、肿瘤坏死因子_α.结果表明 ,经过一周的营养支持 ,与普通肠内营养组相比 ,免疫营养组转铁蛋白、IgA、CD4、CD4/CD8显著增加 ,IgA差值、CD4/CD8差值亦显著增加 .说明肠内免疫营养可有效改善腹部手术创伤后患者营养状况 ,同时可改善患者的免疫功能 。
To evaluate the effect of enteral immunonutrition on host nutritional status and immunity in postoperative patients,a prospective,randomized and controlled trial was performed.Forty patients undergoing abdominal surgery were randomized to receive either immunonutrition or normal nutrition for7days after surgery.The daily nutritional goal was125.4kJ/(kg·d).Nitrogen balance was measured.Weight,mid_arm circumference,skinfold thickness,total albumin,albumin,prealbumin and transferrin were determined as nutritional indicators.Immune responses were investigated by IgG,IgM,IgA,CD4,CD8,CD4/CD8,IL1_α,IL_2,IL_6,IL_10,TNF_α.After a week of nutritional support,in the immunonutrition group,transferrin level,IgA level,CD4and CD4/CD8ratio were higher than those in the control group,and IgA and CD4/CD8recovered more obviously than those in the control group.In conclusion,postoperative administration of immunonutrition in patients can improve nutritional status and enhance patients’immunity.
出处
《南京大学学报(自然科学版)》
CAS
CSCD
北大核心
2004年第2期185-191,共7页
Journal of Nanjing University(Natural Science)