脑卒中患者红细胞衰老因素的探讨

A study on senescence of red blood cell in patients with stroke.

本实验对27例脑梗塞、18例脑出血以及42例同年龄健康对照组测定红细胞丙二醛(MDA)和超氧化物歧化酶(SOD)。结果表明在脑卒中组和对照组之间MDA含量有显著性差异,以及老年组MDA含量又高于老年前期组。因而认为红细胞的这种与年龄有关的脂质过氧化作用是影响卒中发生与转归的伴随因素,值得进一步探讨。此外,本实验未显示SOD含量的显著性差异,认为尚需对实验方法进一步改进。

Measuments of MDA and SOD were performed on the patients with cerebral infarction (27 cases),cerebral hemorrhage (18 cases) and 42 age-matched healthy controls.The results showed that MDA content increased significantly in the patients with stroke than in controls,and in seniles than in preseniles.It was suggested that the peroxidation which damaged the membrane function became stronger in patients than in healthy controls,was related to individual aging.Red cells aging take part in stroke mechanism as an additional factor.There was no difference in SOD content of red cells between patients and controls,no difference between preseniles and seniles.It is doubted if the assay method is insensible and the improvement would be expected.