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Glycodelin在子宫内膜癌和子宫颈癌的表达 被引量：1

The study of Glycodelin expression in endometrial carcinoma and cervical cancer
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摘要 　目的:探讨免疫抑制性糖蛋白(Glycodelin)在子宫内膜癌及子宫颈癌的表达。方法:采用免疫组织化学S-P法检测Glycodelin在30例子宫内膜癌及20例子宫颈癌组织中的表达,并评价其与临床病理分期和组织学分级的关系。结果:Glycodelin在子宫内膜癌、子宫颈鳞癌和子宫颈腺癌的表达率分别为73%(22/30)、53 33%(8/15)和60%(3/5),3组之间无统计学差异(P>0 05)。各临床病理分期的阳性率(子宫内膜癌:I期75%,II期75 00%,III期50%;子宫颈癌:Ia60%,Ib44 44%,IIa66 66%)无统计学差异(P>0 05)。各组织学分级的阳性率(子宫内膜癌:G170%,G277 78%和G366 67%;子宫颈癌:G159 14%,G250 00%和G360 00%)无统计学差异,P>0 05。结论:Glycodelin在子宫内膜腺癌和子宫颈癌均有表达,其表达与临床病理分期和组织学分级无明显关系。 Aim: To study the expression of immunosuppressive glycoprotein Glycodelin in endometrial carcinoma and cervical cancer. Methods: Immunohistochemical S-P assay was used to detect the expression of Glycodelin in paraffin-embedded sections of 30 cases of endometrial carcinoma and 20 cases of cervical cancer. The relationship between Glycodelin expression and clinicopathological characteristics was evaluated. Results: The positive immunostaining rate of Glycodelin in endometrial carcinoma, squamous cell carcinoma of the cervix and adenocarcinoma of the cervix was 73%(22/30), 53.33%(8/15) and 60%(3/5), respectively; there were no significant difference between each group, P>0.05. There were no significant differences between each clinicopathological stage(in endometrial carcinoma: stage I 75.00%, stage II 75.00% and stage III 50%;in cervical cancer:stage Ia 60%,stage Ib 44.44% and stage IIa 66.66%),P>0.05. No significant differences between each histological grade were found (in endometrial carcinoma: G_1 70%, G_2 77.78% and G_3 66.67%;in cervical cancer:G_1 59.14%,G_2 50.00% and G_3 60.00%),P>0.05. Conclusion:Glycodelin is expressed in endometrial carcinoma and cervical cancer,its expression is not correlated with clinicopathological staging or histological grade.
作者 王晓玉 林绍强 朱耀魁 赵营 康举龄
机构地区 暨南大学附属第一医院妇产科 暨南大学医学院免疫学教研室 广州市肿瘤医院妇瘤科
出处 《暨南大学学报（自然科学与医学版）》 CAS CSCD 2004年第2期185-189,共5页 Journal of Jinan University(Natural Science & Medicine Edition)
基金 广东省医学科研课题项目(A2003387)
关键词 免疫抑制性糖蛋白 子宫内膜癌 子宫颈癌 免疫组化 Glycodelin endometrial carcinoma cervical cancer immunohistochemistry
分类号 R733.3 [医药卫生—肿瘤]
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参考文献10

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同被引文献19

  • 1刘红梅,邢福祺,陈士岭.glycodelin在子宫内膜组织中的分泌特点及其与生殖活动的关系[J].中华妇产科杂志,2006,41(11):783-784. 被引量：1
  • 2Jaffe RC, Ferguson - Gottschall SD, Gao W, et al. His- tone deacetylase inhibition and progesterone act synergisti- caUy to stimulate baboon glycodelin gene expression. J Mol Endocrinol, 2007, 38(3): 401 -407.
  • 3Jeschke U, Karsten U, Reimer T, et al. Stimulation of hCG protein and mRNA in first trimester villous cytotrophoblast cells in vitro by glycodelin A. J Perinat Med, 2005, 33 (3) : 212 -218.
  • 4Jeschke U, Richter DU, Reimer T, et al. Glycodelin A and differentation of first trimester trophoblast ceils in vitro. Arch Gynecol Obstet, 2005, 272(2) : 151 -159.
  • 5Mandelin E,Lassus H, Seppala M, et al. Glycodelin in o- varian serous carcinoma: association with differentiation and survival . Cancer Res, 2003, 63 (19) : 6258 - 6264.
  • 6Hayes EC, Dominguez CE, Voelkel S, et al. Effect of gly- codelin on the production of vascular endothelial growth fac- tor in cumulus cells. Fentil Steril, 2006, 85(5) : 1553 - 1556.
  • 7Kunert - Keil C, Wiehm eier E, Jeschke U, et al. Immu- nolocalization of glycodelin in the genital tract of rats. J Mol Histol, 2005, 36 (12) : 111 - 117.
  • 8Foth D, Romer T. Glycodelin serum levels in women with ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol, 2003 ,108(2) : 199-220.
  • 9Telina S, Kauppila A, RonnBerg L, et al. Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis. Am J Obstet Gynecol, 2006 (178) : 866 -871.
  • 10Richter C, Baetje M, Bischof A, et al. Expression of the glycodelin A gene and the detection of its protein in tissues and serum of ovarian carcinoma patients. Anticancer Res, 2007,27(4A) : 2023 -2025.

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暨南大学学报（自然科学与医学版）
2004年 第2期

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