摘要
用双肾双夹法复制易卒中型肾血管性高血压大鼠55只,肾动脉狭窄术后40周内自发脑卒中31只,其中单纯出血或缺血性中风20只(64.5%),混合性中风11只(35.5%)。混合性中风的大鼠脑内细小动脉的透明变性、纤维素样坏死、微动脉瘤形成及增生性反应等病变比单纯出血或缺血性中风者更为广泛、严重。表明高血压是混合性中风的重要病因,高血压性血管损害是其发病基础。本文还根据中风灶的大小将混合性中风进一步分型,并探讨了各型的发生机制。
Fifty-five stroke-prone renovascular hyper-tensive rats (RHRSP) were produced by constrict-ing renal arteries bilaterally in male Sprague-Daw-ley rats. Thirty-one RHRSP suffered from strokespontaneously in 40 weeks after the operation ofrenal artery constriction. There were twenty rats(64. 5%) with ischemic or hemorrhagic stroke andeleven (35. 5%) with mixed stroke (both of freshhemorrhage and infarction in the same brain). InRHRSP with mixed stroke, the cerebral arteriolo-sclerosis that included hyalinosis, fibrinoid necros-is, formation of microaneurysm and hyperplasia,etc, was more estensive and serious than that inRHRSP with ischemic or hemorrhagic stroke. Theseresults suggest that mixed stroke is an importanttype of stroke, its main cause is hypertention. Onthe basis of cerebral arteriolosclerolis, hemorrhagicand ischemic stroke may occur simultaneously oralternately each other in a hypertensive subject.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1992年第6期340-342,共3页
Chinese Journal of Nervous and Mental Diseases
关键词
高血压
动脉硬化
病理学
大鼠
中风
Hypertension Arteriolosclerosis
Cerebrovascular disorder
Pathology Rats