5,7-二甲基-N-芳基-1,2,4-三唑[1,5-a]嘧啶-2-磺酰胺的合成

Synthesis of 5,7-Dimethyl-N-aryl-1,2,4- triazole[1,5-a]pyrimidine-2-sulfonamide

以5-氨基-3-巯基-1,2,4-三唑为原料,经氧氯化后分别与6个芳胺反应,得到5氨基-N-芳基1,2,4-三唑-3-磺酰胺,继而和乙酰丙酮于乙酸中环合,制得6个取代的1,2,4-三唑[1,5-a]嘧啶-2-磺酰胺衍生物,同时讨论了胺解反应和环合反应的影响因素。所有目标产物的结构均经IR和1HNMR谱验证。

5-Amino-3-mercapto-1,2,4-triazole was oxychlorinated with chlorine gas and aminated with arylamine to obtain 5-amino-N-aryl-1,2,4-triazole-3-sulfonamide, which reacted with 2,4-pentanedione to form a series of corresponding substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide derivatives. The factors which influenced amination and cyclization were discussed. The structures of the products were confirmed by IR and ()~1H NMR.