肝循环门静脉系统的压力—流量关系

THE PRESSURE-FLOW RELATIONSHIP OFHEPATIC PORTAL SYSTEM

本文对兔离体肝脏的门静脉系统在门静脉狭窄、肝内阻塞、肝动脉压改变及对照状态下进行了血液动力学方面的动态测量和分析。得到肝脏门静脉系统的压力—流量曲线,通过回归分析,确定其回归方程为Q=a+blnP。经数理统计,找出生理及各种病理模拟状态下具有显著性差异的指标b:在不同程度门静脉狭窄及不同程度肝内阻塞时,组内及各状态之间参数b的均数均有显著差异(P<0.01),在不同的肝动脉压状态下,参数b的均数在组内同样有显著差异(P<0.01)。

<ABSTRACT> The portal vein is the functional vessel of the liver. Either intrahep- atic or extrahepatic portal venous obstruction can cause hemodynamic alt- erations of the portal system. The object of this study is to clarify the hemodynamic characteristics and detect the biomechanical index in differentiation of different patholo- gical states of the hepatic portal system. Measurements and analyses of hemodynamic alterations of the portal system of the rabbit liver in vitro are reported. Experiments were performed under portal venous stenosis, intrahepatic obstruction and different hepatic artery pressure and results were compared with those of control state. This study reveals the relati- onship among pressure, flow, differential conduclance, resistance and compliance of the hepatic portal system in rabbit. In this paper the pre- ssure-flow relationship is emphatically discussed. The pressure-flow relationship of the portal system was obtained by regressive analysis. The regressive equation is Q = a + blnp Statistically, we found that b is an important index. Not only does the index b demonstrate significant differences between mimic physiologi- cal and pathological states but also among different mimic pathological slates. For the states of portal venous stenosis and intrahepatic obstruction of different degrees, the index b manifests significant differences be- tween mimic physiological and pathological states but also among different mimic pathological states as well as within group (P<0.001 ). Under sta- tes of different hepatic artery pressure levels, the index b shows signific- ant difference within group (P<0.01 ). Evidences are given that liver diseases may lead to hemodynamic disturbance of the hepatic portai syst. em. It is thus possible to find out hemodynamic criteria of some diseases of the liver.