复方丹参滴丸治疗抗精神病药所致QTc间期延长临床研究

QTc Prolonging Resulted from the Antipsychotic Drugs together with Composite Salviac Dropping Pill

目的:探讨复方丹参滴丸治疗抗精神病药所致QTc间期延长的疗效及可能机制。方法:首发精神分裂症患者,单一服用某种抗精神病药,首次复查ECG出现QTc>440ms者作为研究对象,给复方丹参滴丸口服,服药期间抗精神病药剂量不变。每周末复查ECG、血K+、心率(HR),研究周期为3周。结果:服用氯氮平、利培酮、舒必利、氯丙嗪等药都可发生QTc间期延长,平均时间为(18.3±4.5)d。经服用复方丹参滴丸后,QTc间期与治疗前比较有明显缩短,差异非常显著(P <0.01),经比较以第1、2周缩短最为显着(P <0.01);治疗前后HR、血K+无明显变化(P > 0.05)。结论:复方丹参滴丸治疗本病疗效确切,可能与心肌细胞内外的离子分布异常得到及时纠正有关。

Objective: To study the efficiency and possible mechanism of QTc prolonging resulted from the antipsychotic drugs together with Composite Salviae Dropping Pill.Methods:The first-episode of schizophrenia were chosen. Anal they took only one kind of antipsychotic drugs.The QTc of ECG(>440ms)were to be studied.They were asked to taken 10 pills three times a day affer meals.At the same time they took the antipsychotic drugs like before.They had ECG,blood K + and HR tested every weekend.Results: Taking Clozapine,Risperldone,Sulpiride and Chlorpromazine resulted in prolonging QTc and the average was l8.3±4.5days QTC is shortened by taking Composite Salviae Dropping Pill(P <0.01).It was obvious in the l st and 2nd weeks during the test(P <0.01).HR and blood K + almost kept the same before and after the treatment (>0.05).Conclusion: It is certain that Composite Salviae Dropping Pill can prolong QTc when it is used to treat Antipsychotic drugs and it is likely to have something to do with the correction of the abnormal ion distribution in and out of cardiac muscle cells.