Graves病患者外周血TNFα的测定及意义

THE DETERMINATION OF SERUM TNFα IN PATIENTS WITH GRAVES DISEASE AND ITS CLINICAL SIGNIFICANCE

目的 :探讨Graves病 (简称GD )时外周血TNFα的变化及其意义。 方法 :采用双抗体夹心ELISA法测定Graves病患者外周血TNFα的水平。结果 :GD各组血清TNFα水平与正常对照组比较均显著增多 (P <0 0 1 ) ,GD复发组血清TNFα水平低于GD未治疗组 (P <0 0 5 )。结论 :血清TNFα水平在GD时显著升高 ,其升高与甲状腺激素无关 ,而与GD自身免疫过程的活性有关。

Objective:To investigate the change of serum tumor necrosis factor α(TNFα) and the relation between TNFα and Graves disease.Methods:TNFα was determined in sera by enzyme linked immunosorbent assay(ELISA).Results:Serum TNFα values increased significantly in untreated GD group compared with those in normal controls and recurrence group.Conclusion:The increase of serum TNFα in untreated GD group has no correlation with thyroid hormone,but has a correlation with autoimmune inflammatory process of Graves disease.