预防仔猪大肠杆菌性腹泻K_(88)遗传工程菌苗免疫途径和剂量的研究

Study on immunizing routes and doses of K_(88) genetic engineering vaccine for prevention of coliform diarrhea in piglets

将61头怀孕母猪分成5个组,给第Ⅰ组皮下注射K_(88)遗传工程菌苗500亿死菌,第Ⅱ、Ⅲ和Ⅳ组分别口服1000亿、500亿和250亿活菌;第Ⅴ组不接种菌苗作为对照。结果各免疫组母猪所生仔猪的发病率明显下降,其中第Ⅲ组的免疫效果最佳。

Sixty one pregnant pigs were divided into five groups, of which the pigs of the group 1 were subcutaneously inoculated inactivated 50 billion bacteria of K_(88) genetic engineering vaccine, and pigs of groups 2, 3 and 4 were administed per os live 100 billion, 50 billion and 25 billion bacteria of the vaccine, respectively. Group 5 wasn't treated as control. The experimental results showed incidence of newborn piglets of each group fell obviously, and imunizing efficacy of the group 3 was the best.