福辛普利与卡托普利对老年高血压病人微量白蛋白尿和肾小球滤过率的影响

A Comparison between The Effects of Fosinopril and Captopril on Microalbuminuria (UAE) and Glomerular Filtration Rate (GFR) in Elderly Hypertensive Patients

目的 观察转换酶抑制剂 (ACEI)对老年高血压病人微量白蛋白尿 (UAE)和肾小球滤过率 (GFR)的影响。比较不同半衰期ACEI药物上述作用的差别。方法 选择 10 8例老年高血压病 2～ 3级患者 ,微量白蛋白尿在64mg～ 5 0 8mg 2 4h。肾小球滤过率在 3 1ml～ 71ml·min- 1 1.73m- 2 之间 ,按序数分成均等二组 :福辛普利组、卡托普利组 ,分别进行治疗前后、二组之间降压幅度、UAE、GFR的比较。结果 福辛普利组、卡托普利组二种药物降压总有效率分别为 94%、93 %、(P >0 .0 5 )。但福辛普利对UAE、GFR的效果明显好于卡托普利 ,二组比较有显著差异性。福辛普利组未见干咳现象 ,而卡托普利组干咳发生率为 16.7%。结论 福辛普利除有良好的降压作用外 ,尚有更好地降低UAE。

Objective To evaluate the effects of Fosinpril and captopril on microalbuminuria (UAE) and glomerular filtration rate (GFR) in elderly patients.Methods In this study,108 elderly patients with stage of the 2～3 class hypertension were included,The patients were divided 2 groups,that were fosinopril group and captopril group,that effects of anti-hypertension and UAE and GFR were determine with assay in before and after the treatment.Results The effective rates of anti-hypertension were 94% in fosinopril group and 93% in captopril group.Decrease of UAE were observed in 89% of patient in fosinopril group and 59% in captopril group.GFR were improved in 94%、78% of patient in fosinopril group and in captopril group.Conclusions Fosinopril has better effects on except UAE and GFR for than Captopril in elderly hypertension patient.