化学发光法检测血清PSA在前列腺疾病中的评价

The Clinical Value Of Serum PSA By Chemiluminescent Immunoassay In Prostate Disease

目的 ①探讨血清前列腺特异抗原 (PSA)在前列腺炎、前列腺增生 (BPH)、前列腺增生并发急性尿潴留(BPH +AUR)、前列腺癌中的鉴别诊断中的意义 ;②了解PSA与年龄的关系。方法 采用化学发光免疫法 (CLIA)检测 5 2例健康体检者 ,5 0例BPH患者 ,3 1例BPH +AUR患者 ,41例前列腺炎患者及 16例前列腺癌患者血清PSA的水平。结果 ① 5 2例健康体检者血清PSA均 <4.0 μg L ,BPH患者与前列腺炎患者的PSA与对照组比较均有显著性意义 (P <0 .0 1) ,前列腺癌与前列腺增生并发急性尿潴留患者PSA水平均明显升高 ,有非常显著性意义 (P <0 .0 0 1) ,但二者PSA值重叠甚多。②PSA水平随着年龄的增加而增加 ,呈正相关关系。结论 ①PSA并非前列腺癌的特异性指标 ,与前列腺增生并发急性尿潴留的鉴别缺乏特异性 ;

Objective ①To evaluate the clinical value of serum prostate specific antigen (PSA) in differentiation among begins prostatitis hyperplasia (BPH), prostate cancer (PCA), BPH with acute urinary retention (BPH+AUR) and prostatitis.② To investigate the correlation between PAS and age.Methods 52 health person, 50 patients with BPH, 31 patients with BPH+AUR, 41 patients with prostatitis and 16 patients with prostate cancer were assayed by chemiluminescent immunoassay.Results ①The normal level of PSA was all less than 4.0μg/L.The difference of serum PSA between control group and that of BPH and prostates was highly significant respectively (P<0.01). PSA of prostate cancer and BPH+AUR were all increased obviously (P<0.001). There were significant differences between them, nevertheless, their PSA value overlap so much.②With the increase of age, the PSA level was increase, there were positive correlation with each other.Conclusions ① PSA was not the specific index of prostate cancer, which was lack of specific in differentiating prostate cancer from BPH+AUR②.When we analyzed the value of PSA, we should consider the influence of age.