绝经后女性2型糖尿病患者血浆性激素变化及其与胰岛素关系的研究

Study of sex hormone changes and the relation between the chonges and insuline in postmenopausal women with type 2 dliabetes mellitus

目的探讨绝经后女性2型糖尿病患者性激素的变化。方法正常绝经后女性76例,2型糖尿病绝经后女性81例,常规检查,采用放射免疫法测定血浆胰岛素、睾酮(Testosterone, T)、雌二醇(Estradiol, E2),促卵泡刺激素(follicle-stimulating hormone, FSH),黄体生成素(Lutenizine hormone, LH)浓度测定。结果观察到绝经后女性2型糖尿病患者血浆性激素改变如下:与正常绝经后女性相比,E2降低,T升高,FSH,LH浓度均升高。绝经后女性2型糖尿病患者性激素与胰岛素之间未发现明显相关性。结论血浆性激素是反映绝经后女性2型糖尿病患者代谢变化的指标之一。

Objective:To investigate the changes of sex hormone in postmenopausal wonen with type2diabetes mellitus.Methods:76postmenopausal women and postmenopausal women81with type2diabetes mellitus were investigated.Testosterone(T),Estradiol(E 2 ),follicle-stimulating hormone(FSH)?Lutenizine hor-mone(LH)?insulin in plasma were determined at the same time by RIA.Results:Compared with that of con-trast group,the levels of plasma testosterone increased,and estradiol decreased in type2diabetic women.It was also showed that the levels of plasma FSH and LH increased in type2diabetic patients.No significant relationship between sex hormone changes and insulin was found in type2diabetic patients.Conclusions:The plasma sex hormone are the perfect index showing the metabolic changes in postmenopausal women with type2diabetes mellitus.