急性心肌梗死患者静脉滴注单硝酸异山梨酯与硝酸甘油疗效比较

Comparison of the effect of isosorbide-5-mononitrate injection and nitroglycerin in acute myocardial infarction patients

目的 比较急性心肌梗死 (AMI)患者静脉滴注单硝酸异山梨酯与硝酸甘油的疗效。方法 对12 8例AMI心功能Ⅱ、Ⅲ级的患者分别静脉滴注单硝酸异山梨酯与硝酸甘油治疗 ,并于治疗前后进行核素心肌显像及核素心室造影 ,以估测心肌缺血面积和判断左室功能变化。结果 两组治疗 3周后心肌缺血面积和心功能较治疗前均有所改善 ,单硝酸异山梨酯治疗效果明显优于硝酸甘油组。梗死后心绞痛与室壁瘤发生率也较对照组明显下降。结论 单硝酸异山梨酯静脉滴注治疗有利于AMI后心肌灌注和心功能的恢复。

Objective To compare the effect of intravenous drip of isosorbide 5 mononitrate(IS 5 MN) and nitroglycerin in acute myocardial infarction(AMI) patients.Methods 128 AMI of grade Ⅱ and Ⅲ cardiac function were treated with IS 5 MN and nitroglycerin.Radionuclide myocardial perfusion imaging and ventriculography were performed to estimate myocardial ischemic area and ventricular function.Results After 3 week treatment,myocardial ischemic area and ventricular function were improved.The effect of IS 5 MN was obviously superior to that of nitroglycerin.The incidence of post infarct angina and ventricular aneurysm was also lower in the IS 5 MN group. Conclusion Intravenous IS 5 MN is beneficial to the improvement of ventricular function and myocardial perfusion after AMI.