长期小剂量吸入糖皮质激素对哮喘儿童骨密度的影响

Effect of long-term corticosteroid on bone mineral density in children with asthma

目的 评估长期小剂量吸入糖皮质激素对哮喘儿童骨密度的影响。方法 随机将 4 5例 5～ 8岁哮喘患儿分为 3个开放治疗组 ,每天吸入糖皮质激素布地奈得 ,剂量分别为 10 0 ,2 0 0和 30 0 μg ,持续 8～ 12个月。于治疗开始、第 6和第 12个月用双能X线骨密度仪监测骨密度 ,同期测量肺功能FEV1。结果 哮喘患儿肺功能FEV1明显改善。治疗前后患儿股骨近端、脊柱区域和前臂的骨密度无显著性降低 (P >0 .0 5 )。结论 长期小剂量吸入糖皮质激素不影响哮喘儿童的骨矿密度。

Objective To evaluate the effect of long term inhaled corticosteroid on bone mineral density(BMD) in children with asthma.Methods 45 patients between 5 8 years old were randomly divided into 3 open groups,who inhaled 100,200 and 300 μg Budesonide per day,for 8 12 months.BMD was examined by dual energy X ray absorptiomtry and lung function(FEV 1) was measured at the beginning of treatment,6 and 12 months.Results FEV 1 in asthmatic children was significantly improved after treatment. BMD was not significantly decreased at the hip,the lumber area of the spine,and forearm after treatment(P>0.05).Conclusion Long term treatment with low dose corticosteroid does not reduce BMD in children with asthma.