免疫球蛋白对川崎病患儿一氧化氮及白细胞介素-6的影响

Effect on Producing of NO and IL-6 by IVIG Treatment in Patients with Kawasaki Disease

目的:了解一氧化氮(NO)、白细胞介素-6(IL-6)在静脉滴注免疫球蛋白(IVIG)治疗川崎病(KD)患儿中的作用及意义。方法:收集38例川崎病患儿,用IVIG治疗前、治疗3d后血液、尿液标本,以30例正常体检同龄儿童作对照:以酶联免疫吸附法测定血清及尿液中NO、IL-6水平。结果:治疗前KD急性期惠儿血清及尿液NO、IL-6较对照组显著增高,经IVIG治疗后,KD患儿血清NO、IL-6及尿液IL-6含量较治疗前显著降低,尿液NO含量无显著变化。结论:KD患儿急性期经IVIG治疗后,通过抑制NO、IL-6等递质的产生,从而减轻炎症损害,使患儿迅速恢复。

Objective: To find the producing effects on nitric oxide (NO) and interleukin-6 (IL-6) in patients with Kawasaki disease (KD) by intravenous immunoglobulin (IVIG) treatment. Methods: Blood and urine samples were collected from 38 patients with KD before IVIG treatment and 3 days later after the treatment. There were 30 age-matched healthy controls in the study. Serum and urinary NO, IL-6 were measured by ELISA. Results: Patients with KD had higher levels of NO and IL-6 than the healthy controls. Serum NO, IL-6, and urinary IL-6 levels significantly decreased after IVIG treatment. The urinary NO levels had no significant change after the treatment. Conclusion: IVIG may inhibit the producing of NO, IL-6 in patients with KD which mediate inflammation responses.