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G蛋白偶联内向整流钾通道亚基2mRNA在颞叶癫大鼠海马内的表达 被引量：1

Expression of G protein inwardly rectifier potassium channels subunit 2 mRNA in hippocampus of temporal epileptic rat
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摘要 目的　探讨G蛋白偶联内向整流钾通道亚基 2 (GIRK 2 )在颞叶癫疒间 大鼠海马内的表达变化。方法　应用腹腔注射海人酸致疒间 大鼠 ,采用原位杂交法检测大鼠海马GIRK 2mRNA的表达。结果　GIRK 2mR NA在癫疒间 大鼠海马齿状回表达增加 ,与正常对照组相比差异有显著性 (P <0 0 1)。结论　癫疒间 大鼠海马内GIRK 2增高是机体对神经元网络过度兴奋的代偿反应。 Objective To explore the expression of G protein inwardly rectifier potassium channels subunit 2(GIRK*!2) in hippocampus of temporal epileptic rat.Methods After temporal lobe epilepsy was induced by kainic acid (KA), we took advantage of in situ hybridization to investigate the altered expression of GIRK*!2 mRNA in rat hippocampus.Results GIRK*!2 mRNA significantly increased in epileptic rats dentate gyrus region compared with normal control( P<0.01).Conclusion Altered expression of GIRK*!2 mRNA is an adaptive response to the over-excitability of neuron networks in epilepsy.
作者 王煜 肖波 杨晓苏 龙小艳
机构地区 中南大学湘雅医院神经内科
出处 《临床神经病学杂志》 CAS 2004年第2期114-116,共3页 Journal of Clinical Neurology
关键词 G蛋白偶联内向整流钾通道亚基2 MRNA表达 颞叶癫痫 大鼠 海马 原位杂交法 检测 Epilepsy G protein inwardly rectifier potassium channels Hippocampus
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献10

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同被引文献6

  • 1刘学伍,迟令懿,陈善红,吴伟,孙建英,王慧煜,迟兆富.海藻氨酸致癫状态大鼠海马区神经元损伤与Mg^(2+)作用的研究[J].临床神经病学杂志,2004,17(5):342-344. 被引量：10
  • 2吴逊主编．癫痢和发作性疾病[M]．第1版．北京：人民军医出版社．2001．68．
  • 3Proper EA, Oestreicher AB, Jansen GH, et al.Immunohistochemicalm characterization of mossy fibre sprouting in the hippocampus of patients with pharamco-resistant temporal lobe epilepsy[ J ]. Brain,2000,123:19.
  • 4Katzir H, Mendoza D, Mathern GW. Effect of theophylline and trimeftobenzamide when given during kainite-induced status epilepticus: an improved histopathologic rat model of human hippocampal sclerosis [ J ]. Epilepsia, 2000,41 : 1390.
  • 5Anatol B, Jerome E, Charles L, et al. Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection[J]. Epilepsia,1999,40:1210.
  • 6张川,申长虹.大鼠海人酸颞叶癫痫模型及病理和致痫机制研究[J].中华实验外科杂志,2003,20(10):918-919. 被引量：20

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临床神经病学杂志
2004年 第2期

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